KPV
What is KPV?
KPV (Lys-Pro-Val) is a tripeptide fragment derived from α-melanocyte-stimulating hormone (α-MSH) studied for its role in inflammatory signaling, immune modulation, and epithelial integrity. In laboratory and preclinical models, KPV has been examined for its interaction with cytokine pathways, NF-κB signaling, and mucosal barrier function, making it a compound of interest in immune and gastrointestinal research.
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KPV Overview
KPV is a short peptide derived from the C-terminal region of α-MSH, studied for its influence on immune signaling, inflammatory response regulation, and epithelial protection pathways. In laboratory models, KPV has been investigated for its ability to interact with pro-inflammatory cytokines, macrophage signaling, and barrier-tissue biology, particularly in gastrointestinal and dermatological research contexts.
- Immune signaling and inflammatory response regulation
- Epithelial protection and mucosal barrier function
- Macrophage activity and cytokine pathway interaction
Ongoing research continues to examine KPV in experimental models focused on immune modulation, gastrointestinal tissue integrity, and inflammatory pathway regulation.
Moss J. et al., 2000History and Development
Research on KPV originates from studies of melanocortin peptides, which revealed that certain short fragments retained biological activity independent of the full α-MSH molecule. KPV was identified as one of the smallest active fragments capable of influencing immune and inflammatory signaling pathways.
Since its discovery, KPV has been studied in experimental models involving intestinal tissue, skin biology, and systemic inflammatory responses, contributing to ongoing research in peptide-mediated regulation of immune function.
Hiltz M.E. & Lipton J.M., 1989KPV Structure
- CAS #: 3061-91-6
- Molecular Formula: C₁₆H₂₈N₆O₅
- Molecular Weight: 388.4 g/mol
- PubChem ID: 16129619
Research Findings
KPV has been studied across immunological, gastrointestinal, dermatological, and systemic research models, with findings highlighting its association with cytokine modulation, epithelial protection, and inflammatory pathway regulation. Research also examines its influence on NF-κB signaling, macrophage activity, and mucosal barrier stability in preclinical settings.
Key Areas of Investigation
- Immune: cytokine signaling, inflammatory modulation
- Gastrointestinal: epithelial integrity, mucosal barrier models
- Dermatological: skin inflammation, tissue response
- Systemic: immune balance, stress response pathways
Together, these findings position KPV as a valuable research compound for studying immune regulation, inflammatory signaling, and barrier-tissue biology in laboratory models.
Moss J. et al., 2000References
- Hiltz M.E. & Lipton J.M. (1989). Antiinflammatory activity of a peptide derived from α-MSH. FASEB Journal, 3(11):2282–2284.
- Moss J. et al. (2000). Anti-inflammatory properties of the tripeptide KPV. Peptides, 21(4):521–530.
- Catania A. et al. (2004). The melanocortin system in inflammatory regulation. Pharmacological Reviews, 56(1):1–29.
