−25%
99.61% purityOriginal COAResearch Use Only
Compound · Neuro
Semax
Research compound · Research Use Only
Semax supplied by Purple Peptides with batch-level documentation. For laboratory research use only.
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$54.99$41.24
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Available original certificates give you a clear record you can open before you order. Research transparency is the standard — not an add-on.
- Batch-level documentation
- Purity verified by HPLC
- Research Use Only supply
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Every vial earns its release through documented proof, not marketing language. Review the supplied certificate for the selected strength. Results apply only to its tested samples; unavailable documentation is marked pending.
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Reported October 3, 2026 · 10mg
Certificate of Analysis
99.61%
Purity by HPLC
- Tested
- October 3, 2026
- Labeled
- 10mg
- Measured
- 12.56 mg
Original certificateReported results
Batch testing
Purity
HPLC-UV · analytical result
99.61%REPORTED
Sample 1 purity
HPLC-UV · sample summary
99.60%REPORTED
Sample 2 purity
HPLC-UV · sample summary
99.62%REPORTED
Identity
LC-MS
SemaxREPORTED
Net content
Reported analytical result
12.56 mgREPORTED
Appearance
Sample summary
White Lyophilized PowderREPORTED
Elemental impurities
ICP-MS · As / Cd / Pb / Hg
Below reporting/specification limits✓ PASS
Microbial analysis
PCR
No Detectable Microbial DNAREPORTED
Endotoxin
USP <85> · LAL
Replicates 1 and 2: Pass · sensitivity ≤0.05 EU/mL✓ PASS
Fentanyl screen
Sample summary
No Fentanyl DetectedREPORTED
Results are transcribed from the supplied original. A reported purity value is not a pass/fail claim. Missing tests are not inferred.
Certificates of Analysis · latest batches
Semax 10mg
99.61% purity (HPLC)
What the standard requires
01
Reported Purity
Exact HPLC-UV results from supplied samples.
02
Double Tested
Manufacturer + independent third-party.
03
Batch Traceable
Chain-of-custody documented end to end.
04
Purple Verified™
Released only after alignment.
Technical specifications
Compound Information
Molecular profile
What Is Semax?
- Category
- Neuro
- Also known as
- ACTH(4–7)-Pro-Gly-Pro · ACTH(4–10) analog
- Classification
- Synthetic heptapeptide · 7 amino acids
- Sequence
- Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
- Molecular Formula
- C₃₇H₅₁N₉O₁₀S
- Molecular Weight
- 813.9 g/mol
- CAS Number
- 80714-61-0
- Form
- Sealed research vial
Storage requirements
Stability Information
Lyophilized (sealed vial)
Storage information pending final content approval.
2–8°C
Reconstituted
Keep refrigerated at 2–8°C after reconstitution.
Reconstituted vials are stored refrigerated at 2–8°C. Remaining Purple-approved storage guidance will appear here once confirmed.
Research overview · preclinical evidence
What the published research investigates.
What is Semax?
Semax is a synthetic heptapeptide built from the ACTH(4–7) fragment extended with a Pro-Gly-Pro sequence. It was developed in Russia, and most of its literature comes from Russian research groups. Published work is mainly animal research, with a smaller number of human reports.
Research areas investigated
Neurotrophin signaling: rat studies examined BDNF and trkB expression in the hippocampus (Dolotov et al., 2006) and neurotrophin gene expression in the brain (Agapova et al., 2007). Ischemia models: gene-expression changes were studied in rat focal cerebral ischemia (Medvedeva et al., 2014). Researchers in this area also study Selank and DSIP.
Human evidence
A small human study reported changes on attention-related measures (Kaplan et al., 1996). Human data are limited, mostly small and from a narrow set of research groups, and do not establish efficacy or safety.
Limitations of the evidence
Most findings come from rodent models. Independent replication is limited and study designs vary. Explore more at the Research Institute.
Peer-reviewed literature
The research behind this compound, cited in full.
Research context on this page traces back to the 4 publications below.
- 01Brain Research · 2006Semax, an analog of ACTH(4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampusDolotov OV, Karpenko EA, Inozemtseva LS, et al.Preclinical (rats): associated with changes in BDNF and trkB expression in the hippocampus.
- 02Neuroscience Letters · 2007Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH4–10Agapova TY, Agniullin YV, Shadrina MI, et al.Preclinical (rats): measured neurotrophin gene expression in brain tissue.
- 03BMC Genomics · 2014The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysisMedvedeva EV, Dmitrieva VG, Povarova OV, et al.Preclinical (rat ischemia model): genome-wide analysis of gene-expression changes.
- 04Neuroscience Research Communications · 1996Synthetic ACTH analogue Semax displays nootropic-like activity in humansKaplan AY, Kochetova AG, Nezavibathko VN, et al.Small human study of attention-related and EEG measures; limited sample.
Research FAQs
Frequently asked questions.
What is Semax?
Semax is a synthetic 7-amino-acid peptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4–7) fragment. Purple Peptides supplies it for laboratory research use only.
What does the scientific literature investigate about Semax?
Published studies examine Semax in rodent models of neurotrophin (BDNF/trkB) expression and cerebral ischemia. See the references on this page.
Is the evidence preclinical or human?
Most published work uses rats. A small number of human studies exist, mainly from Russian groups; they are small and do not establish efficacy or safety.
How is Semax related to ACTH?
Semax contains the ACTH(4–7) sequence followed by Pro-Gly-Pro, which the literature describes as an analog of ACTH(4–10).
What is the difference between peptide identity and purity?
Identity confirms the material is the intended molecule, typically by mass spectrometry. Purity measures how much of the sample is that molecule relative to other detected components, typically by HPLC.
What does Research Use Only mean?
The product is sold exclusively for laboratory research. It is not for human or veterinary use and is not intended to diagnose, treat, cure or prevent any disease. Browse Research Compounds.
Important research notice
Not for human, veterinary, or food use. This product is sold exclusively for laboratory research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
Published research referenced on this page is provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.
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